Bacterial Virulence
Bacterial proteases have been described as the most important class of virulence factors and play a key role in the establishment of wound infections, ultimately impeding the healing response and keeping the wound in a chronic state1Koziel J, Potempa J. Protease-armed bacteria in the skin. Cell Tissue Res. 2013; 351(2): 325-37.. They are produced by both Gram-negative and Gram-positive bacteria associated with chronic wound colonization2Wysocki AB, Bhalla-Regev SK, Tierno PM, Steven-Riley M, Wiygul R. Proteolytic Activity by Multiple Bacterial Species Isolated from Chronic Venous Leg Ulcers Degrades Matrix Substrates. Biol Res Nurs. 2012; 15(4): 407-415..
The detection of bacterial protease activity in a chronic wound would be indicative of the presence of bacterial virulence which is a precursor to clinical signs and symptoms of infection3Thomson PD, Smith DJ. What is infection? Am. J. Surg. 1994; 167(No. 1A): 7S-10S.,4Dow G, Browne A, Sibbald RG. Infection in chronic wounds: Controversies in diagnosis and treatment. Ostomy Wound Management 1999; 45 (8): 23-40. .
Bacterial virulence is undesirable since, at this stage, the wound is in a part of the wound infection continuum that typically requires intervention.
WOUNDCHEK™ Bacterial Status — Now available in countries accepting CE mark or FDA clearance!
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PRODUCT CODE |
DESCRIPTION |
CONTAINS |
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360006 |
WOUNDCHEK™ Bacterial Status |
6 tests (all material needed) |
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360010 |
WOUNDCHEK™ Bacterial Status |
3 positive & 3 |
Videos
Evidence
Posters & Articles
Serena, T. et al. 2017. A Rapid Point of Care Test for Bacterial Protease in Chronic Wounds is Predictive of Amputation Risk
Serena, T. et al. 2015. Bacterial proteases: A marker for a 'state of pathogenesis' in chronic wounds
Serena, T. et al. 2015. Bacterial protease activity in chronic wound fluid, a potential indicator of pathogenicity even in the absence of overt signs of infection.
Benson, R. et al. 2013. Bacterial protease activity, an indicator of bacterial pathogenicity in chronic wounds even in the absence of overt clinical signs.
Consensus Documents
Wound Infection in Clinical Practice, International Wound Infection Institute, 2016
BPA Made Easy Wounds International, Serena T., et al, 2016
The Use of a point-of-care test for bacterial protease activity in chronic wounds Wounds International 2015, Vol 6 Issue 4
Symposia
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